Watch the video:
Timestamps:
0:00 - Explanation
0:20 - Windows Update
0:43 - Updating graphics drivers
1:16 - Check hardware compatibility
2:12 - Run Rainbow 6: Siege as Admin
3:11 - Fixing overlays
3:24 - Other fixes
Having some issues starting or playing Rainbow 6: Siege in Vulkan mode? This video covers some possible solutions that can help, from updating drivers to running the game in compatibility mode.
Nvidia Drivers: https://www.nvidia.com/Download/index.aspx?lang=en-us
AMD Graphics Drivers: https://www.amd.com/en/support
Ubisoft Vulkan Help: https://support.ubisoft.com/en-GB/Faqs/000052839/Unable-to-launch-Rainbow-Six-Siege-on-Vulkan-API-R6S